義大大昌醫院胃腸肝膽科 主任

論文

Publications

1. Lin CW, Lin CC, Lee PH, Lo GH, Hsieh PM, Koh KW, Lee CY, Chen YL, Dai CY, Huang JF, Chuang WL, Chen YS, Yu ML.
The autophagy marker LC3 strongly predicts immediate mortality after surgical resection for hepatocellular carcinoma. Oncotarget. 2017 (accepted, in press).

2. Hsu YC, Mo LR, Chang CY, Wu MS, Yang TH, Kao JH, Chen CC, Tseng CH, Tai CM, Lin CW, Wu CY, Lin JT.
Serum viral load at the virological relapse predicts subsequent clinical flares in chronic hepatitis B patients off entecavir therapy. J Gastroenterol Hepatol. 2017; 32(8):1512-1519.

3. Tsai IT, Wang CP, Yu TH, Lu YC, Lin CW, Lu LF, Wu CC, Chung FM, Lee YJ, Hung WC, Hsu CC.
Circulating visfatin level is associated with hepatocellular carcinoma in chronic hepatitis B or C virus infection. Cytokine. 2017; 90:54-59.

4. Lu IC, Jean MC, Lin CW, Chen WH, Perng DS, Lin CW, Chuang HY.
Predictive factors for anti-HBs status after 1 booster dose of hepatitis B vaccine. Medicine (Baltimore). 2016; 95(39):e5023.

5. Lin CW, Chen YS, Lin CC, Chen YJ, Lo GH, Lee PH, Kuo PL, Dai CY, Huang JF, Chung WL, Yu ML.
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy. Scientific Reports. 2015; 5:15807-15819.

6. Hung TM, Yuan RH, Huang WP, Chen YH, Lin YC, Lin CW, Lai HS, Lee PH.
Increased Autophagy Markers Are Associated with Ductular Reaction during the Development of Cirrhosis. Am J Pathol. 2015; 185(9):2454-67.

7. Lin CW, Lo S, Hsu C, Hsieh CH, Chang YF, Hou BS, Kao YH, Lin CC, Yu ML, Yuan SS, Hsieh YC.
T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis. PLoS One. 2014; 9(7):e102066.

8. Lin CW, Steven Lo, Perng DW, David Bin-Chia Wu, Lee PH, Chang YF, Kuo PL, Yu ML, Yuan SSF, Hsieh YC.
Complete activation of autophagic process attenuated liver injury and improves survival in septic mice. Shock. 2014; 41(3):241-9.

9. Hung CM, Huang WC, Pan HL, Chien PH, Lin CW, Chen LC, Chien YF,Lin CC, Leow KH,Chen WS, Chen JY, Ho CY, Hou PS, Chen YJ.
Hepatitis B virus X up-regulates HuR protein level to stabilize HER2 expression in hepatocellular carcinoma cells. BioMed Res Int. 2014; 2014:827415.

10. Perng DS, Lu IC, Shi HY, Lin CW, Liu KW, Su YF, Lee KT.
Incidence trends and predictors for cost and average lengths of stay in colorectal cancer surgery. World J Gastroenterol. 2014; 20(2):532–538.

11. Lo GH, Lin CW, Perng DS, Chang CY, Lee CT, Hsu CY, Wang HM, Lin HC.
A retrospective comparative study of histoacryl injection and banding ligation in the treatment of acute type 1 gastric variceal hemorrhage. Scand J Gastroenterol. 2013; 48(10):1198-204.

12. Chen YJ, Chien PH, Chen WS, Chien YF, Hsu YY, Wang LY, Chen JY, Lin CW, Huang TC, Yu YL, Huang WC.
Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2013; Vol 2013, Article ID 682389, 10 Pages.

13. Lin CW*, Zhang H*, Li M, Xiong XW, Chen X, Chen XY, Dong XC, Yin XM.
Pharmacological Promotion of Autophagy Alleviates Steatosis and Injury in Alcoholic and Nonalcoholic Fatty Liver Conditions in Mice. J. Hepatology. 2013; 58(5):993-999.

14. Lin CW, Lin CC, Mo LR, Chang CY, Perng DS, Hsu CC, LO GH, Yen YC, Hu JT, Yu ML, Lee PH, Lin JT, Yang SS.
Heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis. J. Hepatology. 2013; 58(4):730-735.

15. Hung KC, Hsieh PM, Hsu CY, Lin CW, Feng GM, Chen YS, Hung CH.
Expression of aquaporins in rat liver regeneration. Scand J Gastroenterol. 2012; 47(6):676-685.

16. Hsu YC, Mo LR, Chang CY, Perng DS, Tseng CH, Lo GH, Tai CM, Lin CW, Hsu CC, Hsu CY, Huang SC, Lin JT.
Entecavir versus lamivudine in the treatment of chronic hepatitis B patients with hepatic decompensation. Antiviral therapy. 2012; 17(4):605-12.

17. Lin CW, Mars WM, Paranjpe S, Donthamsetty S, Bhave VS, Kang LI, Orr A, Bowen WC, Bell AW, Michalopoulos GK.
Hepatocyte Proliferation and Hepatomegaly Induced by Phenobarbital and TCPOBOP is Suppressed in Hepatocyte-Targeted Glypican 3 Transgenic Mice. Hepatology. 2011; 54:620-630.

18. Chang CY, Wu MS, Lee CT, Hwang JC, Tai CM, Perng DS, Lin CW, Wang WL, Wang JD, Lin JT.
Prospective survey for the etiology and outcome of peptic ulcer bleeding: a community based study in southern Taiwan. J Formos Med Assoc. 2011; 110:223-229.

19. Ding WX, Li M, Chen XY, Ni HM, Lin CW, Gao WT, Lu BF, Stolz DB, Clemens DL, Yin XM.
Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology. 2010; 139:1740-1752.

20. Lin CC, Mohamed E, Hidetaka H, Long C, Lin CW, Dorling A, Cooper DKC.
Atorvastatin or transgenic expression of TFPI inhibits coagulation initiated by anti-nongal IgG binding to porcine aortic endothelial cells. J Thromb Haemost. 2010; 8: 2001-2010.

21. Lin CW, Chen YS, Lai CH, Perng DS, Weng HS, Hu JT, Huang YW, Hsu MY, Yang SS.
Esophagogastric varices predicts mortality in hospitalized patients with alcoholic liver disease. Hepato-gastroenterology. 2010; 57:305-308.

22. Shi YH, Fan J, Lin CW, Ding WX; Yin XM.
Molecular Pathology of Liver disease: Macroautophagy. Springer. 2010; Chapter 26; 389-396.

Conference attended

1. Poster presentation: Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Kah Wee Koh, Chia-Yen Dai,Jee-Fu Huang, Wang-Long Chuang, Ming-Lung Yu.
Autophagy in tumors and the liver microenvironment strongly predict hepatocellular carcinoma recurrence after curative resection. The Liver Meeting 2017 of the American Association for the Study of Liver Diseases (2017 AASLD; Washington DC). Hepatology, Vol 66(1) Suppl. Page 736A, Abstract #1371. 國際性研討會,多位作者(第一作者)

2. Poster presentation: Chih-Wen Lin, Gin-Ho Lo, Chia-Chang Hsu, Kah Wee Koh, Pei-Min Hsieh, Yaw-Sen Chen.
The autophagy marker predicts tumor recurrence in intrahepatic cholangiocarcinoma patients after surgical resection. EASL Monothematic conference 2017, pAGE 203-204, OSLO, Norway. June 2017. 國際性研討會,多位作者(第一作者)

3. Poster presentation: Chih-Wen Lin, Ming-Jong Bair, Chia-Chang Hsu, Daw-Shyong Perng, Ming-Lung Yu, Sien-Sing Yang.
The histological assessment of hepatitis B viral activity in patients with heavy alcohol consumption. The 26th Conference of the APASL Annual Meeting, 上海, 2017.02 國際性研討會,多位作者(第一作者)

4. Poster presentation: Chih-Wen Lin, Yaw-Sen Chen, Chia-Chang Hsu, Daw-Shyong Perng, Gin-Ho Lo, Chi-Yang Chang.
Alcoholism concomitant with viral hepatitis increases the prevalence of HCC in Taiwan. 25th Asian Pacific Association for the Study of the Liver (APASL 2016) “Modern Hepatology” 日本東京, 2016.02 國際性研討會,多位作者(通訊作者)

5. Poster presentation: Chih-Wen Lin, Chia-Yen Dai, Jhy-Shrian Huang, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu.
The autophagy marker LC3 is significantly associated with recurrence in human hepatocellular carcinoma underwent resection. The Liver Meeting 2015, USA, San Francisco 2015.11 國際性研討會,多位作者(第一作者)

6. Poster presentation: Chih-Wen Lin, Gin-Ho Lo, Chia-Chang Hsu, Daw-Shyong Perng, Pei-Min Hsieh, Yaw-Sen Chen.
The autophagy-related marker beclin-1 is significantly associated with clinical prognosis in human hepatocellular carcinoma. UEG Week 2015, Barcelona, 2015.10 國際性研討會,單一作者

7. Oral presentation: Chih-Wen Lin, Yaw-Sen Chen, Chia-Chang Hsu, Gin-Ho Lo, Chia-Yen Dai, Wan-Loug Chuang, Ming-Lung Yu.
Promotion of autophagy using amiodarone increased the survival and alleviates liver injury following 90% massive hepatectomy. 24th Conference of APASL 2015 ISTANABUL, Turkey, 2015.03 國際性研討會,多位作者(第一作者).

8. Poster presentation: Chih-Wen Lin, Chia-chang Hsu, Daw-Shyong Perng, Pei-Min Hsieh, Yaw-Sen Chen.
Liver resection is a better survival than sorafenib in hepatocellular carcinoma patients in Barcelona clinic liver cancer stage C with macro vascular invasion. 2014 UEG, Vienna Austria, Vienna, Austria, 2014.10 國際性研討會,多位作者(第一作者)

9. Poster presentation: Chih-Wen Lin, Lein-Ray Mo, Gin-Ho Lo, Chia-Chang Hsu, Chuan-Yuan Hsu, Pei-Min Hsieh, Yaw-Sen Chen.
Surgical resection increases the survival of selected hepatocellular carcinoma patients in Barcelona clinic liver cancer stage C with vascular invasion. 49th European Association for the Study of the Liver (2014 EASL), pp.S395, .London, UK, 2014.04 國際性研討會,多位作者(第一作者)

10. Poster presentation: Chih-Wen Lin, Lein-Ray Mo, Yaw-Sen Chen, Yun-Ju Chen, Po-Lin Kuo, Ming-Lung Yu.
Enhanced autophagy promotes liver regeneration and hepatocyte proliferation after partial hepatectomy in mouse liver. 64st Annual Meeting of the American Association for the Study of Liver Diseases, Washington DC, 2013.11國際性研討會,多位作者(第一作者)

11. Poster presentation: Chih-Wen Lin, Lein-Ray Mo, Chi-Yang Chang, Daw-ShyongPerng, Gin-Ho Lo, Sien-Sing Yang, Po-Huang Lee, Jaw-Town Lin.
Heavy alcohol intake increases hepatocellular carcinoma in hepatitis B virus-related cirrhosis. 48 th European Association for the Study of the Liver (2013 EASL) Netherlands

12. Poster presentation: Enhanced autophagy promotes liver regeneration and hepatocyte proliferation after partial hepatectomy in mouse liver. Chih-Wen Lin, Lein-Ray Mo, Yaw-Sen Chen, Yun-Ju Chen, Po-Lin Kuo, Ming-Lung Yu.
64st Annual Meeting of the American Association for the Study of Liver Diseases (2013 AASLD; Washington DC). 專書

1. Chih-Wen Lin, Chih-Che Lin and Sien-Sing Yang.
Advances in Treatment of Hepatitis C and B: Chapter 11: Treatment and Prognosis of Hepatitis B Virus Concomitant with Alcoholism ISBN 978-953-51- 2994-3, Print ISBN 978-953- 51-2993- 6, Published: March 8, 2017 under CC BY 3.0 license. Publisher: InTechOpen, Croatia

2. Ying-Hong Shi, Jia Fan, Chih-Wen Lin, Wen-Xing Ding and Xiao-Ming Yin
Macroautophagy and Liver Pathobiology", Springer US, NEW YORK,5位作者, 2010/11