用法用量 |
Acute myeloid leukemia(AML), newly diagnosed
Ramp up dosage: 100 mg PO on day 1, 200 mg on day 2, and 400 mg on day 3
Usual dosage: beginning on day 4, 400 mg PO once daily when given with azacitidine or decitabine or 600 mg once daily when given with low-dose cytarabine
Chronic lymphoid leukemia(CLL)
Ramp-up dosage: 20 mg PO once daily during week 1; 50 mg once daily during week 2; 100 mg once daily during week 3; 200 mg once daily during week 4, then 400 mg once daily during week 5.
(1)Monotherapy: after completion of 5-week ramp-up schedule, 400 mg orally once daily until disease progression or unacceptable toxicity.
(2)Combination with obinutuzumab: start obinutuzumab at 100 mg on cycle 1 day 1, followed by 900 mg on cycle 1 day 2; administer 1000 mg on days 8 and 15 of cycle 1, followed by 1000 mg on day 1 of each subsequent 28-day cycle, for a total of 6 cycles; on cycle 1 day 22, start venetoclax according to the 5-week ramp-up schedule until cycle 2 day 28; continue venetoclax 400 mg orally once daily from cycle 3 day 1 until the last day of cycle 12.
(3)Combination with rituximab: start rituximab after completion of the 5-week venetoclax dose ramp-up schedule and patient has received the venetoclax 400 mg dose for 7 days; give rituximab on day 1 of each 28-day cycle for 6 cycles, with rituximab 375 mg/m(2) IV for cycle 1 and 500 mg/m2 IV for cycles 2 to 6; continue venetoclax 400 mg once daily for 24 months from cycle 1, day 1 of rituximab. |
副作用 |
Leukopenia, diarrhea, upper respiratory tract infection, cough, nausea |