用法用量 |
Multiple myeloma newly diagnosed, in combination with dexamethasone:
PO 25mg once daily for 21 days of a 28-day cycle plus low-dose dexamethasone 40mg orally once daily on days 1, 8, 15, and 22 of each 28-day cycle, continue until disease progression or unacceptable toxicity.
Multiple myeloma newly diagnosed, in combination with melphalan and prednisolone:
PO 10mg once daily for 21 days of a 28-day cycle plus melphalan 0.18 mg/kg and prednisone 2 mg/kg orally once daily on days 1-4 day of each 28-day cycle up to 9 cycles, then Lenalidomide 10mg once daily for 21 days of a 28-day cycle, continue until disease progression or unacceptable toxicity.
Multiple myeloma previously treated, in combination with dexamethasone:
PO 25mg once daily for 21 days of a 28-day cycle plus low-dose dexamethasone 40mg orally once daily on days 1-4, 9-12, and 17-20 of each 28-day cycle for the first 4 cycles, then reduce to dexamethasone 40 mg once daily on days 1-4 of each 28-day cycle; continue until disease progression or unacceptable toxicity. |