Deferasirox

Jadenu

解鐵定膜衣錠

360mg/tab

18. ANTIDOTES; ;

18.02. FOR IRONS;;

Chelating Agent

(1)治療因輸血而導致慢性鐵質沈著症。(2)非輸血依賴型海洋性貧血患者之慢性鐵質沉著症

C 動物試驗顯示有致畸胎的結果，但沒有針對孕婦或動物有對照組的研究可證明其危險性。

Unknown

Transfusional iron overload
PO Initial 14 mg/kg once daily
An initial daily dose of 21mg/kg may be considered for patients receiving more than 14mL/kg/month of packed red blood cells(>4 units/month for an adult), and for whom the objective is reduction of iron overload.
An initial daily dose of 7mg/kg may be considered for patients receiving more than 7mL/kg/month of packed red blood cells(<2 units/month for an adult), and for whom the objective is reduction of iron overload.
Iron overload in Non-Transfusion dependent thalassemia syndromes
PO Initial 7mg/kg once daily
After 3-6 months of treatment, consider a dose increase in increments of 3.5-7mg/kg.
if hepatic iron concentration: (Dependent upon serum ferritin measurements monthly)
(1)>7 mg Fe/g dry weight: Increase dose up to 14 mg/kg/day; Maximum dose: 14 mg/kg/day
(2)≦7 mg Fe/g dry weight: Continue treatment at a dose of no more than 7 mg/kg/day
(3)<3 mg Fe/g dry weight: Interrupt therapy
註:Exjade125mg與Jadenu360mg之不同劑量的轉換請參考藥品說明書

Nausea, vomiting, diarrhea, abdominal pain, skin rash

eGFR<40mL/min or Scr >2times the age-appropriate upper limit of normal、高危險群骨髓增生不良症候群(MDS)、因疾病快速惡化而無法自螯合劑療法獲益之惡性腫瘤患者。

1.無法吞服整粒藥錠患者，可磨碎後加入軟質食物(如優格或蘋果泥)混合後立即服用。
2.高脂食物會增加藥物血中濃度，建議可空腹或輕食併服。
3.開始治療前應測量腎功能(血清肌胺酸酐濃度及肌胺酸酐清除率)、肝功能(血清轉胺酶及膽紅素濃度)，之後應每個月監測肝腎功能。
4.可能有頭暈不良反應，如有此情形開車或操作機器時應小心。
5.磨碎後的Jadenu應立刻使用完畢，避免潮濕。

與高脂食物併服時，Deferasirox的 Cmax 會些微提升(約29%)。建議可以空腹服用或與輕食併服

建立者

104784

建立時間

2017-11-03 14:49:57

維護者

103617

維護時間

2022-09-27 11:13:57