Vancomycin

Vanco

安克乾粉注射劑

1 g/vial

03. ANTIMICROBIALS; ;

03.18. MISCELLANEOUS;;

Methicillin-resistant staphylococcus aureus (MRSA) or cephalosporin- allergic patients, prophylaxis for endocarditis, pseudomembranous colitis

葡萄球菌感染所導致之心內膜炎、骨髓炎、肺炎、敗血病、軟組織感染、腸炎、梭狀桿菌感染所致之假膜性結腸炎

C 動物試驗顯示有致畸胎的結果，但沒有針對孕婦或動物有對照組的研究可證明其危險性。

Unsafe

IVF
Neonate & infant: initial 15mg/kg followed by 10mg/kg q8-12h
Children: 40mg/kg/day in 2-4 divided doses
Adults: 15-20mg/kg q8-12h

PO (for Pseudomembranous colitis, PMC)
Adult:0.5-2g/day tid-qid for 7-10 days
Children: 40mg/kg/day tid-qid for 7-10 days

其他參考資料
Neonatal(Uptodate)
General dosing, susceptible infection, non-CNS involvement
Loading dose(postnatal age ≤60 days):IVF 20 mg/kg once, followed by maintenance dose
Maintenance dose
Gestational Age(GA)≤28 weeks and Scr <0.5 mg/dL: 15 mg/kg/dose q12h
GA≤28 weeks and Scr 0.5-0.7 mg/dL: 20 mg/kg/dose q24h
GA≤28 weeks and Scr 0.8-1 mg/dL:15 mg/kg/dose q24h
GA≤28 weeks and Scr 1.1-1.4 mg/dL: 10 mg/kg/dose q24h
GA≤28 weeks and Scr >1.4 mg/dL: 15 mg/kg/dose q48h
GA>28 weeks and Scr <0.7 mg/dL: 15 mg/kg/dose q12h
GA>28 weeks and Scr 0.7-0.9 mg/dL: 20 mg/kg/dose q24h
GA>28 weeks and Scr 1 to 1.2 mg/dL: 15 mg/kg/dose q24h
GA>28 weeks and Scr 1.3 to 1.6 mg/dL: 10 mg/kg/dose q24h
GA>28 weeks and Scr >1.6 mg/dL: 15 mg/kg/dose q48h

Stomatitis, chills, drug fever, eosinophilia, thrombocytopenia, ototoxicity, renal failure, interstitial nephritis, Stevens-Johnson syndrome

1.給藥速率過快會造成Red man syndrome
2.乾粉以20ml注射用水溶解，可冷藏96小時。再以200ml NS、D5W、LR稀釋後在室溫下可保存24小時
3.給藥速率：Adults：≧60min（或＜10mg/min）.Children、neonate & infant：≧60min.

建立者

100224

建立時間

維護者

103617

維護時間

2021-02-25 10:04:13