Penicillin G

Penicillin

永豐芐基青黴素鈉注射劑

3,000,000U/vial

03. ANTIMICROBIALS; ;

03.13. PENICILLINS;;

3.13.1. Natural Penicillins

Treatment of infections caused by penicillin-sensitive organisms, eg: meningitis, pneumonia, endocarditis, GI, skin & soft tissue infection, syphilis, gonorrhea etc

抗生素

B 動物試驗中無法證實對胎兒有害，但沒有以人做較嚴謹的研究。或動物試驗報告對胎兒有害，但對懷孕婦女有對照組的研究中無法證明對胎兒有害。

Safe

Adult:IM/slow IVP
Clostridium perfringens:24MU/day q4-6h with clindamycin
Fascial space infections:2-4MU q4-6h with metronidazole
Leptospirosis:1.5MU q6h for 7 days
Listeria:15-20 MU/day q4-6h for 2wks(meningitis) or 4wks(endocarditis)
Neurosyphilis:18-24MU/day q4h or continuous infusion for 10-14days
Streptococcus:
Brain abscess 18-24MU/day q4h with metronidazole
Endocarditis 3-4MU q4h or continuous infusion for least 4wks
Osteomyelitis 3-4MU q4h for least 4wks
Pregnancy (prophylaxis GBS) 5MU x 1 dose, then 2.5MU q4h until delivery
Skin and soft tissue 3-4MU q4h for 10days
Toxic shock 24MU/day in divided dose with clindamycin
Streptococcal pneumonia:2-3MU q4h

Pediatric
Susceptible infections :Infants>1mon or Children 100,000~400,000 U/kg/day IM, slow IVP q4-6h; max: 24MU/day
Community-acquired pneumonia (CAP)
Empiric or S. pneumonia: 200,000~250,000 U/kg/day q4-6h
Group A Streptococcus: 100,000~250,000U/kg/day q4-6h
Meningitis (gonococcal): 250,000U/kg/day IVP q6h
Moderate infection: 100,000~250,000U/kg/day IM, IVP q6h
Severe infection: 250,000~400,000U/kg/day IVP q4-6h;max:24MU/day
Neurosyphilis:200,000~300,000U/kg/day q4-6h for 10-14days; max:24MU/day
Congenital syphilis: IVP
Infants: 50,000U/kg q12h for first 7days of life, then q8h for total 10days
Children: 50,000U/kg q4-6h for 10days

Convulsions, confusion, drowsiness, myoclonus, fever, rash, electrolyte imbalance, hemolytic anemia, thrombophlebitis, interstitial nephritis, anaphylaxis, Jarisch-Herxheimer reaction

1.第一次使用penicillin類之抗生素，之前從未使用過之病患，則建議執行penicillin skin test。
2.加入5ml0.9% NaCl或Dextrose或注射用水，震搖後可得6ml(濃度為0.5MU/ml)，再依據醫囑抽取所需量稀釋。溶解藥粉後於2-8℃可存放3天

建立者

100224

建立時間

維護者

103617

維護時間

2019-11-19 11:29:14