用法用量 |
IVF(rate: over 2 hours)
Acute myeloid leukemia, CD33 positive, newly diagnosed de novo
Combination therapy: Induction 3 mg/m2 (maximum: 4.5 mg/dose) on days 1, 4, and 7 (in combination with daunorubicin and cytarabine). If a second induction cycle is required, do NOT administer gemtuzumab ozogamicin during that second induction cycle.
Consolidation (2 cycles): 3 mg/m2 (maximum: 4.5 mg/dose) on day 1 (in combination with daunorubicin and cytarabine).
Single-agent regimen:
Induction: 6 mg/m2 on day 1 (no maximum dose) followed by 3 mg/m2 (no maximum dose) on day 8.
Continuation: 2 mg/m2 (no maximum dose) on day 1 every 4 weeks for up to 8 continuation cycles.
Acute myeloid leukemia, CD33 positive, relapsed/refractory
3 mg/m2 (maximum: 4.5 mg/dose) on days 1, 4, and 7 (as monotherapy); treatment consists of a single course of therapy. |