Apomorphine

Apo-go pen

帕特捷筆型注射液

30mg/3ml/pen

12. NEUROLOGYS; ;

12.05. PARKINSONIAN AGENTS;;

12.05.01 DOPAMINERGICS

Dopamine Agonist

改善巴金森氏病後期藥效波動現象

Unknown

SC
Parkinson disease, "off" episode Determination of the threshold dose
SC 1mg of apomorphine, that is approximately 15-20mcg/kg, may be injected subcutaneously during a hypokinetic, or “off” period and the patient is observed over 30 minutes for a motor response.
If no response, or an inadequate response, is obtained a second dose of 2mg of apomorphine is injected subcutaneously and the patient observed for an adequate response for a further 30 minutes.
Precautions on continuing treatment
The daily dose of apomorphine varies widely between patients, typically within the range of 3-30mg, given as 1-10 injections and sometimes as many as 12 separate injections per day.

Hallucinations, transient sedation, somnolence, yawning, nausea, vomiting

有呼吸衰竭、失智、精神疾病或肝功能不足病人；對levodopa治療時產生嚴重異動症或肌張力不全之”on”反應的病人；兒童和18歲以下青少年

1.注射期間劑量可漸進式增加，每次增加劑量時間至少間隔40分鐘
2.啟用48小時後需丟棄。若注射液變為綠色時請勿使用
3.可能引起低血壓，對已有心臟疾病或是使用影響血管之藥物(如：降血壓藥)治療，即使已先服用了 domperidone亦須小心。對患有姿勢性低血壓的病人，尤需特別注意
4.可能發生嗜/猝睡現象，開車或操作機械應小心。
5.如果所需使用劑量為1mg，則須在第一次注射前，先行將前1mg量排空並丟棄；而後設妥所需劑量，再依下述注射方法注射給藥。若所需劑量超過1mg，則不需排空前 1mg 量。

建立者

103617

建立時間

2023-03-07 10:57:33

維護者

103617

維護時間

2023-03-07 10:59:34